Sildenafil boosts the result of NO by inhibiting phosphodiesterase type 5 (PDE5), that's accountable for degradation of cGMP during the corpus cavernosum. Sildenafil has no direct relaxant impact on isolated human corpus cavernosum. From Mayo Clinic to the inbox Enroll in cost-free and keep up-to-date on study enhancements, wellness suggestions, https://janestevensnutrition.com