Chemotherapy was potentiated by E7449 and single agent had considerable antitumor activity in BRCA-deficient xenografts. Moreover, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, likely through TNKS inhibition. In keeping with this probability, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and drastically altered expression of Wnt https://isaacn429dil2.mybuzzblog.com/profile